Champions Leicester travel to Chelsea to kick off the action on a Saturday on which leaders Manchester City face fifth-placed Everton and there is a London derby between Crystal Palace and West Ham.
The biggest game of this round of fixtures, however, comes on Monday as Liverpool take on Manchester United.
Here are some of the main talking points, as well as our guide of how to follow the action on the BBC.
Will Conte be laughing again?
Former England midfielder Jermaine Jenas told BBC Radio 5 live: "I think Conte will be happy with how things have started to develop but he is clearly not comfortable with what he is seeing in a back four. He's been going with three at the back and two midfield enforcers."
Can Swans spark negative virus - again?
After a 35-year journey to the Premier League, which began at Ohio Bobcats, Bob Bradley has promised a "fresh start" at Swansea, who are 17th in the table.
Positivity in south Wales, then - something Arsenal manager Arsene Wenger craves.
The Frenchman this week reflected on the "negativity" sweeping Emirates Stadium after their home defeat by Swansea in March, adding: "It is a virus that travels very quickly and goes away very slowly."
The Gunners have not lost since the opening day, have kept four straight clean sheets and have Alexis Sanchez back in form with four goals in five games.
But the Chilean flew about 15,000 miles during the international break.
Former England midfielder Leon Osman on BBC Radio 5 live: "Bradley was a surprise appointment for me. I thought he'd maybe come in at Championship level but I wasn't in the interview room. Swansea have found it difficult to get back to what they were. Are they still that passing team?"
Risk Aguero? 'Mini-crisis' looming?
Sergio Aguero has scored 28 goals in his past 28 Premier League appearances for Manchester City. But, after flying roughly the same distance as Sanchez, will he start a potentially tricky home match against Everton on Saturday.
Aguero played 163 minutes, nursed a calf complaint and missed a penalty as Argentina drew with Peru and lost to Paraguay during the international break.
City boss Pep Guardiola said the 28-year-old and fellow forwards Kevin de Bruyne and Raheem Sterling are "much, much better" after recent injuries.
But will they play as the Blues look to bounce back from a first defeat of the season at Tottenham, or will they be saved for a Champions League trip to Barcelona?
Everton are fifth but without a win in two league games, and manager Ronald Koeman said: "We know we can be better."
Osman: "No-one would be surprised if City were beaten at the Nou Camp, so if the Everton game doesn't go well they are on a bad four-game streak and people start asking questions - is there a mini-crisis? That type of thing starts to breed into the club."
Who will be the last winless team?
Stoke and Sunderland face each other at the Bet365 Stadium on Saturday (15:00 BST) as the only winless sides in the Premier League.
But both have come close to notching that elusive victory in recent games.
Sunderland threw away a 2-0 lead to lose 3-2 at home to Crystal Palace on September 24, the same day Stoke conceded in injury time to draw 1-1 with West Brom.
Stoke manager Mark Hughes said the onus is on his side to be positive in a match "we need to win and feel we can win".
Sunderland counterpart David Moyes, meanwhile, said he will "find a way" to get three points.
What are the weekend's fixtures?
Saturday (15:00 BST unless stated)
Chelsea v Leicester (12:30 BST)
Arsenal v Swansea
Bournemouth v Hull
Manchester City v Everton
Stoke v Sunderland
West Brom v Tottenham
Crystal Palace v West Ham (17:30 BST)
BBC Sport Reports